ω-3PUFA supplementation ameliorates adipose tissue inflammation and insulin-stimulated glucose disposal in subjects with obesity: a potential role for apolipoprotein E.
James D HernandezTing LiCassandra M RauWilliam E LeSuerPanwen WangDawn K ColettaJames A MaduraElizabeth A JacobsenEleanna De FilippisPublished in: International journal of obesity (2005) (2021)
High dose of long chain ω-3PUFA supplementation modulates significant changes in plasma fatty acid profile, AT, and systemic inflammation. These findings are associated with significant improvement of insulin-stimulated glucose disposal. Unbiased microarray analysis of Sc fat biopsy identified APOE as among the most differentially regulated gene after ω-3PUFA supplementation. We speculate that ω-3PUFA increases macrophage-derived APOE mRNA levels with anti-inflammatory properties.
Keyphrases
- adipose tissue
- type diabetes
- high fat diet
- insulin resistance
- high dose
- fatty acid
- anti inflammatory
- glycemic control
- blood glucose
- metabolic syndrome
- oxidative stress
- weight loss
- transcription factor
- low dose
- genome wide
- copy number
- gene expression
- high fat diet induced
- skeletal muscle
- risk assessment
- binding protein
- fine needle aspiration