Hidden agenda of <i>Enterococcus faecalis</i> lifestyle transition: planktonic to sessile state.

<i>Enterococcus faecalis</i>, a human gastrointestinal tract commensal, is known to cause nosocomial infections. Interestingly, the pathogen's host colonization and persistent infections are possibly linked to its lifestyle changes from planktonic to sessile state. Also, the multidrug resistance and survival fitness acquired in the sessile stage of <i>E. faecalis</i> has challenged treatment regimes. This situation exists because of the critical role played by several root genes and their molecular branches, which are part of quorum sensing, aggregation substance, surface adhesions, stress-related response and sex pheromones in the sessile state. It is therefore imperative to decode the hidden agenda of <i>E. faecalis</i> and understand the significant factors influencing biofilm formation. This would, in turn, augment the development of novel strategies to tackle <i>E. faecalis</i> infections.