The Neutrophil to Lymphocyte and Lymphocyte to Monocyte Ratios as New Prognostic Factors in Hematological Malignancies - A Narrative Review.
Paulina StefaniukAgnieszka SzymczykMonika PodhoreckaPublished in: Cancer management and research (2020)
Despite the presence of many hematological prognostic indexes, clinical course and overall survival are often highly variable even within the same patient subgroup. Recent studies suggest that simple, cost-effective, low-risk tests such as neutrophil to lymphocyte ratio (NLR) and lymphocyte to monocyte ratio (LMR) may be used to evaluate the prognosis. Their role has been well confirmed in diffuse large B-cell lymphoma (DLBCL), Hodgkin lymphoma (HL) and multiple myeloma (MM), but until now the prognostic significance of NLR and LMR in leukemias has not been widely reported. In this article, we analyze the literature data on prognostic value of NLR and LMR in haematological malignancies in the context of classic prognostic factors and clinical course.
Keyphrases
- prognostic factors
- diffuse large b cell lymphoma
- peripheral blood
- hodgkin lymphoma
- epstein barr virus
- dendritic cells
- multiple myeloma
- endothelial cells
- systematic review
- case report
- big data
- electronic health record
- randomized controlled trial
- immune response
- free survival
- case control
- data analysis
- placebo controlled