Associations of Polypharmacy and Inappropriate Medications with Adverse Outcomes in Older Adults with Cancer: A Systematic Review and Meta-Analysis.
Mostafa R S MohamedErika RamsdaleKah Poh LohAsad ArastuHuiwen XuSpencer ObrechtDaniel CastilloManvi SharmaHolly M HolmesGinah NightingaleKatherine M JubaSupriya G MohilePublished in: The oncologist (2019)
Polypharmacy and potentially inappropriate medications (PIM) are prevalent in older adults with cancer. This systematic review summarizes the associations of polypharmacy and PIM with health outcomes in older patients with cancer. Polypharmacy and PIM have been associated with postoperative complications, frailty, falls, medication nonadherence, chemotherapy toxicity, and mortality. These findings emphasize the prognostic importance of careful medication review and identification of PIM by oncology teams. They also underscore the need to develop and test interventions to address polypharmacy and PIM in older patients with cancer, with the goal of improving outcomes in these patients.
Keyphrases
- community dwelling
- adverse drug
- physical activity
- systematic review
- papillary thyroid
- end stage renal disease
- middle aged
- squamous cell
- healthcare
- newly diagnosed
- chronic kidney disease
- oxidative stress
- randomized controlled trial
- squamous cell carcinoma
- prognostic factors
- lymph node metastasis
- type diabetes
- electronic health record
- childhood cancer
- cardiovascular events
- meta analyses
- peritoneal dialysis
- emergency department
- coronary artery disease
- metabolic syndrome
- young adults
- locally advanced
- risk factors
- adipose tissue
- oxide nanoparticles
- bioinformatics analysis