miR-34a regulates macrophage-associated inflammation and angiogenesis in alcohol-induced liver injury.
Ying WanElise SlevinSachiko KoyamaChiung-Kuei HuangAshok K ShettyXuedong LiKelly HarrisonTian LiBingru ZhouSugeily Ramos LorenzoYudian ZhangJennifer Mata SalinasWenjuan XuJames E KlaunigChaodong WuHidekazu TsukamotoFanyin MengPublished in: Hepatology communications (2023)
Our results show that miR-34a-mediated Sirt1 signaling in macrophages is essential for steatohepatitis and angiogenesis during alcohol-induced liver injury. These findings provide new insight into the function of microRNA-regulated liver inflammation and angiogenesis and the implications for reversing steatohepatitis with potential therapeutic benefits in human alcohol-associated liver diseases.