Efficacy versus effectiveness: The HORIZON Pivotal Fracture Trial and its emulation in Claims Data.

Elvira D'AndreaSebastian SchneeweissJessica M FranklinSeoyoung C KimRobert J GlynnSu Been LeeShirley V Wang

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

Real-world emulation of the HORIZON-PFT found that zoledronic acid reduced hip fractures risk over an 18-month follow-up period. Limited adherence in clinical practice diminished the magnitude of its preventive effect and precluded long-term estimation of effectiveness in this setting.

Keyphrases

clinical practice
randomized controlled trial
systematic review
study protocol
clinical trial
health insurance
big data
type diabetes
metabolic syndrome
adipose tissue
skeletal muscle