A male-specific mechanism of meningeal nociceptor sensitization promoting migraine headache.

Caroline M KopruszinskiGrace LeeLaurent K MartinKara R BarberAubin MoutalDavid W DodickEdita NavratilovaFrank Porreca

Published in: Cephalalgia : an international journal of headache (2024)

Our studies reveal a male-specific mechanism of TG nociceptor sensitization and migraine-like pain behavior mediated by orexin B/OX2R signaling. Sexually dimorphic mechanisms of trigeminal nociceptor sensitization and activation offer opportunities to improve patient outcomes by considering patient sex and may influence clinical trial design and interpretation.

Keyphrases

clinical trial
neuropathic pain
chronic pain
pain management
case report
genome wide
randomized controlled trial
spinal cord injury
double blind
case control