Maternal Intake of Probiotics to Program Offspring Health.
Céline CuinatSara E StinsonWendy E WardElena M ComelliPublished in: Current nutrition reports (2022)
Effects were investigated in the context of supporting offspring growth, intestinal health, and gut microbiota, preventing allergic diseases, supporting neurodevelopment, and preventing metabolic disorders in pre-clinical and clinical studies. Most human studies focused on infancy outcomes, whereas pre-clinical studies also examined outcomes at adolescence and young adulthood. While still understudied, both pre-clinical and clinical studies propose epigenetic modifications as an underlying mechanism. Optimal timing of intervention remains unclear. Administration of selected probiotics to mothers has programming potential for sustaining life-long health of offspring. Administration protocols, specific windows of susceptibility, and individual-specific responses need to be further studied.
Keyphrases
- quality improvement
- high fat diet
- healthcare
- public health
- mental health
- depressive symptoms
- randomized controlled trial
- endothelial cells
- gene expression
- health information
- dna methylation
- weight gain
- human health
- health promotion
- body mass index
- pregnant women
- birth weight
- atomic force microscopy
- high resolution
- single molecule
- solid state