Ganoderma lucidum, a medicinal mushroom with a long history in traditional Chinese medicine, is widely used for chronic diseases. Ganospirones A-G (1-7), seven pairs of undescribed spiro-meroterpenoids, were isolated from the fruiting bodies of G. lucidum. Their structures including absolute configurations were characterized by using NMR spectroscopic data, ECD computational and X-ray diffraction methods. The anti-inflammatory and anti-renal fibrosis activities of the meroterpenoids 1-7 were tested, and the results revealed that (-)-2 and (+)-2 could inhibit iNOS expression in lipopolysaccharide-induced RAW264.7 cells at 20 μM.
Keyphrases
- lipopolysaccharide induced
- high resolution
- inflammatory response
- anti inflammatory
- induced apoptosis
- poor prognosis
- cell cycle arrest
- magnetic resonance
- molecular docking
- electronic health record
- single cell
- endoplasmic reticulum stress
- signaling pathway
- cell death
- magnetic resonance imaging
- long non coding rna
- machine learning
- crystal structure
- pi k akt
- cell proliferation
- liver fibrosis
- contrast enhanced