Sickle Cell Anemia Patients Display an Intricate Cellular and Serum Biomarker Network Highlighted by TCD4+CD69+ Lymphocytes, IL-17/MIP-1β, IL-12/VEGF, and IL-10/IP-10 Axis.
Nadja Pinto GarciaAlexander Leonardo S JúniorGeyse Adriana S SoaresThainá Cristina C CostaAlicia Patrine C Dos SantosAllyson Guimarães CostaAndréa Monteiro TarragôRejane Nina MartinsFlávia do Carmo Leão PontesEmerson Garcia de AlmeidaErich Vinícius de PaulaOlindo Assis Martins-FilhoAdriana MalheiroPublished in: Journal of immunology research (2020)
In the SCA pathophysiology at steady state, there is a broad immunological biomarker crosstalk highlighted by TCD4+CD69+ lymphocytes, IL-12 and IL-17 inflammatory and IL-10 regulatory cytokines, MIP-1α, MIP-1β, and IP-10 chemokines, and VEGF growth factor. High expression of TLR2 in monocytes and VLA-4 in TCD8+ lymphocytes and high levels of MIP-1β and RANTES appear to be relevant in high death risk conditions. The high reticulocytosis and high death risk conditions present common correlations, and there seems to be a balance by the Th2 profile.