α-Synuclein V15A Variant in Familial Parkinson's Disease Exhibits a Weaker Lipid-Binding Property.
Kensuke DaidaShotaro ShimonakaKahori Shiba-FukushimaJun OgataHiroyo YoshinoAyami OkuzumiTaku HatanoYumiko MotoiTomoki HirunagiMasahisa KatsunoHideo ShindouManabu FunayamaKenya NishiokaNobutaka HattoriYuzuru ImaiPublished in: Movement disorders : official journal of the Movement Disorder Society (2022)
The discovery of the V15A variant from Japanese families reinforces the possibility that the V15A variant may be a causative variant for developing PD. V15A had a reduced affinity for phospholipids and increased propagation activity compared with wild-type. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.