Single-Cell Sequencing Reveals Trajectory of Tumor-Infiltrating Lymphocyte States in Pancreatic Cancer.

Aislyn Schalck Donastas Sakellariou-Thompson Marie-Andrée Forget Emi Sei Tara G Hughes Alexandre Reuben Shanshan BaiMin HuTapsi Kumar Mark W Hurd Matthew H G Katz Ching-Wei D Tzeng Shubham Pant Milind M Javle David R Fogelman Anirban Maitra Cara L Haymaker Michael P Kim Nicholas E Navin Chantale Bernatchez

Published in: Cancer discovery (2022)

To improve the efficacy of immunotherapy in PDAC, there is a great need to understand the PDAC TIL landscape. This study represents a reference of PDAC TIL subpopulations and their relationships and provides a foundation upon which to base future immunotherapeutic efforts. This article is highlighted in the In This Issue feature, p. 2221.

Keyphrases

single cell
rna seq
high throughput
machine learning
deep learning
quality improvement