Caffeine modulates glucocorticoid-induced expression of CTGF in lung epithelial cells and fibroblasts.

Markus FehrholzKirsten GlaserChristian P SpeerSilvia SeidenspinnerBarbara OttensmeierSteffen Kunzmann

Published in: Respiratory research (2017)

In addition to well-known anti-inflammatory features, glucocorticoids may have adverse effects on long-term remodeling by TGF-β1-independent induction of CTGF in lung cells. Simultaneous treatment with caffeine may attenuate glucocorticoid-induced expression of CTGF, thereby promoting restoration of lung homeostasis.

Keyphrases

poor prognosis
high glucose
diabetic rats
anti inflammatory
induced apoptosis
binding protein
long non coding rna
transforming growth factor
epithelial mesenchymal transition
signaling pathway
cell death