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Glyoxal-derived advanced glycation end-products, N ε -carboxymethyl-lysine, and glyoxal-derived lysine dimer induce apoptosis-related gene expression in hepatocytes.

Jison KangYu-Jin JeongSang Keun HaHyun Hee LeeKwang-Won Lee
Published in: Molecular biology reports (2023)
These findings suggest that AGE5 treatment activates the apoptosis-related gene expression in hapatocytes, with CML and GOLD as potential major AGE compounds.
Keyphrases
  • gene expression
  • oxidative stress
  • dna methylation
  • endoplasmic reticulum stress
  • cell cycle arrest
  • cell death
  • liver injury
  • replacement therapy
  • chronic myeloid leukemia