The autism-associated loss of δ-catenin functions disrupts social behaviors.
Hadassah Mendez-VazquezRegan L RoachKaila NipMatheus F SathlerTyler GarverRosaline A DanzmanMadeleine C MoseleyJessica P RobertsOlivia N KochAva A StegerRahmi LeeJyothi ArikkathSeonil KimPublished in: bioRxiv : the preprint server for biology (2023)
gene is found in autism patients and results in the loss of δ-catenin functions. δ-catenin expression is also closely linked to other autism-risk genes involved in synaptic structure and function, further implying that it is important for the autism pathophysiology. Importantly, social dysfunction is a key characteristic of autism. Nonetheless, the links between δ-catenin functions and social behaviors are largely unknown. The significance of the current research is thus predicated on filling this gap by discovering the molecular, cellular, and synaptic underpinnings of the role of δ-catenin in social behaviors.
Keyphrases
- autism spectrum disorder
- intellectual disability
- epithelial mesenchymal transition
- cell proliferation
- healthcare
- mental health
- end stage renal disease
- chronic kidney disease
- poor prognosis
- ejection fraction
- oxidative stress
- signaling pathway
- peritoneal dialysis
- copy number
- genome wide
- patient reported outcomes
- binding protein
- prefrontal cortex
- single molecule