Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins.

Gabin DrouardFiona A HagenbeekAlyce M WhippRené PoolJouke Jan HottengaRick JansenNikki HubersAleksei Afoninnull nullGonneke WillemsenEco J C de GeusSamuli RipattiMatti PirinenKatja M KanninenDorret I BoomsmaJenny van DongenJaakko Kaprio

Published in: BMC medicine (2023)

Associations between the proteome and BMI trajectories are characterized by shared genetic, environmental, and metabolic etiologies. We observed few gene-protein pairs associated with BMI or changes in BMI at the proteome and transcriptome levels.

Keyphrases

body mass index
young adults
weight gain
genome wide
depressive symptoms
single cell
copy number
mental health
gene expression
rna seq
physical activity
cross sectional
amino acid
small molecule