IGF1 and Insulin Receptor Single Nucleotide Variants Associated with Response in HER2-Negative Breast Cancer Patients Treated with Neoadjuvant Chemotherapy with or without a Fasting Mimicking Diet (BOOG 2013-04 DIRECT Trial).
Nadia de GruilStefan BöhringerStefanie de GrootHanno PijlJudith R KroepJesse Joachim SwenPublished in: Cancers (2023)
variants rs3743259 and rs3743258 are negatively associated with pathological response in this cohort, suggesting potential relevance as a predictive biomarker. Further research is needed to validate these findings and elucidate the underlying mechanisms and interaction with FMD.
Keyphrases
- neoadjuvant chemotherapy
- copy number
- locally advanced
- type diabetes
- lymph node
- sentinel lymph node
- physical activity
- clinical trial
- study protocol
- weight loss
- binding protein
- randomized controlled trial
- squamous cell carcinoma
- skeletal muscle
- blood pressure
- dna methylation
- risk assessment
- breast cancer risk
- double blind