Anlotinib Enhances the Therapeutic Effect of Bladder Cancer with GSDMB Expression: Analyzed from TCGA Bladder Cancer Database & Mouse Bladder Cancer Cell Line.

Chen WangQifeng CaoShun ZhangHailong LiuHuangqi DuanWeimin XiaHaibo ShenCheng Wang

Published in: Pharmacogenomics and personalized medicine (2023)

Anlotinib has a strong antitumor effect on GSDMB-positive bladder tumors. This effect is mainly achieved by anlotinib stimulating the secretion of relevant antitumor factors by lymphocytes. The PI3K/AKT and MEK signal transduction pathways were inhibited by Anlotinib in bladder cancer expressing GSDMB protein.

Keyphrases

poor prognosis
spinal cord injury
emergency department
adverse drug
pi k akt
electronic health record
urinary tract
drug induced