Meta-analyses of genome wide association studies in lines of laying hens divergently selected for feather pecking using imputed sequence level genotypes.
Clemens Falker-GieskeHanna IfflandSiegfried PreußWerner BesseiCord DrögemüllerJörn BennewitzJens TetensPublished in: BMC genetics (2020)
We provide evidence for the involvement of numerous genes in the propensity to exhibit FP behavior that could aid in the selection against this unwanted trait. Furthermore, we identified variants that are involved in phosphatidylinositol signaling, Golgi metabolism and cell structure and therefore propose changes in brain structure to be an influential factor in FP, as already described in human neuropsychiatric disorders.
Keyphrases
- meta analyses
- genome wide association
- genome wide
- heat stress
- endothelial cells
- systematic review
- copy number
- single cell
- randomized controlled trial
- cell therapy
- resting state
- dna methylation
- endoplasmic reticulum
- multiple sclerosis
- gene expression
- transcription factor
- mesenchymal stem cells
- brain injury
- cerebral ischemia
- functional connectivity
- bioinformatics analysis
- amino acid