Neutrophil extracellular traps formation is associated with postoperative complications in neonates and infants undergoing congenital cardiac surgery.

Wiriya MaisatLifei HouSumiti SandhuYi-Cheng SinSamuel KimHanna Van PeltYue ChenSirisha EmaniSek Won KongSitram EmaniJuan IblaKoichi Yuki

Published in: bioRxiv : the preprint server for biology (2023)

Neonates and infants showed highest postoperative complications with more upregulation of inflammatory transcriptomes of neutrophils.Neonates and infants with organ dysfunction had more NETs formation with higher plasma histones and HMGB1 levels.

Keyphrases

cardiac surgery
low birth weight
oxidative stress
acute kidney injury
preterm infants
cell proliferation
single cell
poor prognosis
signaling pathway