Altered Expression of CD44, SIRT1, CXCR4, miR-21, miR-34a, and miR-451 Genes in MKN-45 Cell Line After Docetaxel Treatment.
Maryam MotamediFarnaz RazmkhahLeila RezakhaniSorayya GhasemiPublished in: Journal of gastrointestinal cancer (2021)
DOC treatment affected CD44+ cell frequency in MKN-45 cell line and induced significant changes in the expression of SIRT1, CXCR4, miR-21, miR-451, and miR-34a that are implicated in stemness and chemo-radioresistance, which might offer new insights for future GC therapies.
Keyphrases
- cell proliferation
- long non coding rna
- long noncoding rna
- poor prognosis
- stem cells
- gene expression
- dna methylation
- combination therapy
- mesenchymal stem cells
- ischemia reperfusion injury
- high resolution
- binding protein
- genome wide
- cell therapy
- endothelial cells
- rectal cancer
- transcription factor
- diabetic rats
- dna damage
- dna repair
- replacement therapy