Telomerase and mitochondria inhibition promote apoptosis and TET2 and ANMT3a expression in triple negative breast cancer cell lines.

Zeinab MazloumiAli RafatKhadijeh Dizaji AslMohammad KarimipourDariush ShanehbandiMehdi TalebiMajid MontazerAli Akbar MovassaghpourAlireza DehnadRaheleh FarahzadiHojjatollah Nozad Charoudeh

Published in: BioImpacts : BI (2023)

The inhibition of telomerase and mitochondria respiration caused intrinsic- and extrinsic- apoptosis and increased DNMT3a and TET2 expression and it could be utilized in breast cancer treatment.

Keyphrases

cell death
poor prognosis
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
dna methylation
binding protein
reactive oxygen species
long non coding rna
gene expression
signaling pathway
cell proliferation