Toll-like receptor 2 induced senescence in intervertebral disc cells of patients with back pain can be attenuated by o-vanillin.
Matthew MannarinoHosni CherifLi LiKai ShengOded RabauPeter JarzemMichael H WeberJean A OuelletLisbet HaglundPublished in: Arthritis research & therapy (2021)
Taken together our data demonstrate that activation of TLR-2/6 induce senescence and increase TLR-2 and SASP expression in cells from non-degenerate IVDs of organ donors without degeneration and back pain and in cells from degenerating human IVD of patients with disc degeneration and back pain. The senescent cells showed high TLR-2 expression suggesting a link between TLR activation and cell senescence in human IVD cells. The reduction in senescence, SASP, and TLR-2 expression suggest o-vanillin as a potential disease-modifying drug for patients with disc degeneration and back pain.
Keyphrases
- toll like receptor
- endothelial cells
- inflammatory response
- induced apoptosis
- nuclear factor
- immune response
- poor prognosis
- cell cycle arrest
- dna damage
- endoplasmic reticulum stress
- stress induced
- cell death
- binding protein
- single cell
- stem cells
- induced pluripotent stem cells
- machine learning
- cell proliferation
- mesenchymal stem cells
- deep learning
- artificial intelligence
- kidney transplantation