HPV16 E6/E7 expression in circulating tumor cells in oropharyngeal squamous cell cancers: A pilot study.

Panagiota EconomopoulouGeorge KoutsodontisMargaritis AvgerisAreti StratiChristos KroupisIoannis PaterasEuthymios KirodimosEvangelos GiotakisIoannis KotsantisPavlos MaragoudakisVassilis GorgoulisAndreas ScorilasEvi LianidouAmanda Psyrri

Published in: PloS one (2019)

Detection of HPV E6/E7(+) CTCs might be a useful noninvasive test in liquid biopsy samples for determination of a clinically relevant HPV infection in HPV+ OPSCC. Combined interpretation of HPV E6/E7(+) CTCs with UICC staging data may lead to alteration of risk definition of patient subsets, with improved risk discrimination in early-stage disease.

Keyphrases

circulating tumor cells
high grade
early stage
cervical cancer screening
squamous cell
poor prognosis
circulating tumor
squamous cell carcinoma
radiation therapy
pet ct
electronic health record
high resolution
quantum dots
real time pcr
tandem mass spectrometry
breast cancer risk