Oncogene-Driven Non-Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations.
Chen-Yang HuangNanhai JiangMeixin ShenGillianne G Y LaiAaron C TanAmit JainStephanie P L SawMei Kim AngQuan Sing NgDarren Wan-Teck LimRavindran KanesvaranEng Huat TanWan Ling TanBoon-Hean OngKevin L M ChuaDevanand AnanthamAngela M TakanoTony Kiat Hon LimWai Leong TamNgak Leng SimAnders Jacobsen SkanderupDaniel Shao-Weng TanSteven G RozenPublished in: Cancer research (2024)
Non-small cell lung cancers driven by nonsmoking-related oncogenes do not harbor genomic scars caused by smoking regardless of smoking history, indicating that the impact of smoking on these tumors is mainly nongenomic.