Wai Leong Tam

Scopus Author ID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 39

Top Venues

Nature communications

Nature cell biology

Genome medicine

Cancer research

Nanyang Technological University

National University of Singapore (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Nanyang Technological University Apr 01 2017

Singapore

Assistant Professor (Adjunct) :: School of Biological Sciences

Cancer Science Institute of Singapore Nov 27 2015

Singapore

Principal Investigator

National University Singapore Yong Loo Lin School of Medicine Aug 01 2015

Singapore

Assistant Professor (Adjunct) :: Department of Biochemistry

Genome Institute of Singapore Oct 01 2014

Singapore

Principal Investigator

Whitehead Institute for Biomedical Research Apr 01 2009 - Oct 01 2014

United States

Postdoctoral Fellow

Genome Institute of Singapore Aug 01 2008 - Mar 31 2009

Singapore

Research Fellow :: Stem Cell and Developmental Biology

Education History

National University of Singapore Aug 01 2003 - Aug 01 2008

Singapore

PHD

Genome Institute of Singapore Aug 01 2003 - Aug 01 2008

Singapore

PHD

National University of Singapore Aug 01 1999 - Aug 01 2003

Singapore

BSC :: Department of Biological Sciences; University Scholars Programme; Special Programme in Science

Publications

Maria P Alcolea, Direna Alonso-Curbelo, Chiara Ambrogio, Susan Bullman, Ana Luísa Correia, Aurélie Ernst, Christopher J Halbrook, Gemma L Kelly, Amanda W Lund, Abdel Razaq Ahmad A Alyasin, Marcus Ruscetti, Efrat Shema, Ingunn M Stromnes, Wai Leong Tam
Cancer Hallmarks: Piecing the Puzzle Together. Cancer discovery 14 (4) (2024)
Yi Fei Lee, Cheryl Zi Jin Phua, Ju Yuan, Bin Zhang, May Yin Lee, Srinivasaraghavan Kannan, Yui Hei Jasper Chiu, Casslynn Wei Qian Koh, Choon Kong Yap, Edwin Kok Hao Lim, Jianbin Chen, Yuhua Lim, Jane Jia Hui Lee, Anders Jacobsen Skanderup, Zhenxun Wang, Weiwei Zhai, Nguan Soon Tan, Chandra S Verma, Yvonne Tay, Daniel Shao-Weng Tan, Wai Leong Tam
PARP4 interacts with hnRNPM to regulate splicing during lung cancer progression. Genome medicine 16 (1) (2024)
Yi Fei Lee, Cheryl Zi Jin Phua, Ju Yuan, Bin Zhang, May Yin Lee, Srinivasaraghavan Kannan, Yui Hei Jasper Chiu, Casslynn Wei Qian Koh, Choon Kong Yap, Edwin Kok Hao Lim, Jianbin Chen, Yuhua Lim, Jane Jia Hui Lee, Anders Jacobsen Skanderup, Zhenxun Wang, Weiwei Zhai, Nguan Soon Tan, Chandra S Verma, Yvonne Tay, Daniel Shao-Weng Tan, Wai Leong Tam
PARP4 interacts with hnRNPM to regulate splicing during lung cancer progression. Genome medicine 16 (1) (2024)
Yi Fei Lee, Cheryl Zi Jin Phua, Ju Yuan, Bin Zhang, May Yin Lee, Srinivasaraghavan Kannan, Yui Hei Jasper Chiu, Casslynn Wei Qian Koh, Choon Kong Yap, Edwin Kok Hao Lim, Jianbin Chen, Yuhua Lim, Jane Jia Hui Lee, Anders Jacobsen Skanderup, Zhenxun Wang, Weiwei Zhai, Nguan Soon Tan, Chandra S Verma, Yvonne Tay, Daniel Shao-Weng Tan, Wai Leong Tam
PARP4 interacts with hnRNPM to regulate splicing during lung cancer progression. Genome medicine 16 (1) (2024)
Chen-Yang Huang, Nanhai Jiang, Meixin Shen, Gillianne G Y Lai, Aaron C Tan, Amit Jain, Stephanie P L Saw, Mei Kim Ang, Quan Sing Ng, Darren Wan-Teck Lim, Ravindran Kanesvaran, Eng Huat Tan, Wan Ling Tan, Boon-Hean Ong, Kevin L M Chua, Devanand Anantham, Angela M Takano, Tony Kiat Hon Lim, Wai Leong Tam, Ngak Leng Sim, Anders Jacobsen Skanderup, Daniel Shao-Weng Tan, Steven G Rozen
Oncogene-Driven Non-Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations. Cancer research 84 (12) (2024)
Chen-Yang Huang, Nanhai Jiang, Meixin Shen, Gillianne G Y Lai, Aaron C Tan, Amit Jain, Stephanie P L Saw, Mei Kim Ang, Quan Sing Ng, Darren Wan-Teck Lim, Ravindran Kanesvaran, Eng Huat Tan, Wan Ling Tan, Boon-Hean Ong, Kevin L M Chua, Devanand Anantham, Angela M Takano, Tony Kiat Hon Lim, Wai Leong Tam, Ngak Leng Sim, Anders Jacobsen Skanderup, Daniel Shao-Weng Tan, Steven G Rozen
Oncogene-driven non-small cell lung cancers in patients with a history of smoking lack smoking-induced mutations. Cancer research (2024)
Yi Fei Lee, Leilei Chen, Valerie Chew, Edward Kai-Hua Chow, Lih-Wen Deng, Walter Hunziker, Ann Siew Gek Lee, Geraldine Leong, Joanne Ngeow Yuen Yie, Shazib Pervaiz, Kanaga Sabapathy, Anders Jacobsen Skanderup, Raghav Sundar, Yvonne Tay, David M Virshup, Sunny-Hei Wong, Vinay Tergaonkar, Wai Leong Tam
Pushing the Frontiers of Cancer Research: Highlights from the Frontiers in Cancer Science Conference 2023. Cancer research 84 (8) (2024)
May Yin Lee, Wai Leong Tam
Multimodal metabolomics pinpoint new metabolic vulnerability in colorectal cancer. Nature metabolism (2023)
Xun Hui Yeo, Vignesh Sundararajan, Zhengwei Wu, Zi Jin Cheryl Phua, Yin Ying Ho, Esther Kai Lay Peh, Yi-Chia Chiu, Tuan-Zea Tan, Dennis Kappei, Ying Swan Ho, David Shao Peng Tan, Wai Leong Tam, Ruby Yun-Ju Huang
The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer. Communications biology 6 (1) (2023)
Jieqiong Zhang, Zhenhua Hu, Hwa Hwa Chung, Yun Tian, Kah Weng Lau, Zheng Ser, Yan Ting Lim, Radoslaw Mikolaj Sobota, Hwei Fen Leong, Benjamin Jieming Chen, Clarisse Jingyi Yeo, Shawn Ying Xuan Tan, Jian Kang, Dennis Eng Kiat Tan, Ieng Fong Sou, Urszula Lucja McClurg, Manikandan Lakshmanan, Thamil Selvan Vaiyapuri, Anandhkumar Raju, Esther Sook Miin Wong, Vinay Tergaonkar, Ravisankar Rajarethinam, Elina Pathak, Wai Leong Tam, Ern Yu Tan, Wee-Wei Tee
Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis. Nature communications 14 (1) (2023)
Xiaosai Yao, Jing Han Hong, Amrita M Nargund, Michelle Shu Wen Ng, Hong Lee Heng, Zhimei Li, Peiyong Guan, Masahiro Sugiura, Pek Lim Chu, Loo Chien Wang, Xiaofen Ye, James Qu, Xiu Yi Kwek, Jeffrey Chun Tatt Lim, Wen Fong Ooi, Joanna Koh, Zhenxun Wang, You-Fu Pan, Yan Shan Ong, Kiat-Yi Tan, Jian Yuan Goh, Sheng Rong Ng, Luca Pignata, Dachuan Huang, Alexander Lezhava, Su Ting Tay, Minghui Lee, Xun Hui Yeo, Wai Leong Tam, Sun Young Rha, Shang Li, Ernesto Guccione, P Andrew Futreal, Jing Tan, Joe Poh Sheng Yeong, Wanjin Hong, Robert Yauch, Kenneth Tou-En Chang, Radoslaw Mikolaj Sobota, Patrick Boon-Ooi Tan, Bin Tean Teh
PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma. Nature cell biology (2023)
Xiaosai Yao, Jing Han Hong, Amrita M Nargund, Michelle Shu Wen Ng, Hong Lee Heng, Zhimei Li, Peiyong Guan, Masahiro Sugiura, Pek Lim Chu, Loo Chien Wang, Xiaofen Ye, James Qu, Xiu Yi Kwek, Jeffrey Chun Tatt Lim, Wen Fong Ooi, Joanna Koh, Zhenxun Wang, You-Fu Pan, Yan Shan Ong, Kiat-Yi Tan, Jian Yuan Goh, Sheng Rong Ng, Luca Pignata, Dachuan Huang, Alexander Lezhava, Su Ting Tay, Minghui Lee, Xun Hui Yeo, Wai Leong Tam, Sun Young Rha, Shang Li, Ernesto Guccione, P Andrew Futreal, Jing Tan, Joe Poh Sheng Yeong, Wanjin Hong, Robert Yauch, Kenneth Tou-En Chang, Radoslaw Mikolaj Sobota, Patrick Boon-Ooi Tan, Bin Tean Teh
PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma. Nature cell biology 25 (5) (2023)
Teresa Lai Fong Ho, May Yin Lee, Hui Chin Goh, Germaine Yi Ning Ng, Jane Jia Hui Lee, Srinivasaraghavan Kannan, Yan Ting Lim, Tianyun Zhao, Edwin Kok Hao Lim, Cheryl Zi Jin Phua, Yi Fei Lee, Rebecca Yi Xuan Lim, Perry Jun Hao Ng, Ju Yuan, Dedrick Kok Hong Chan, Bettina Lieske, Choon Seng Chong, Kuok Chung Lee, Jeffrey Hy Lum, Wai Kit Cheong, Khay-Guan Yeoh, Ker Kan Tan, Radoslaw Mikolaj Sobota, Chandra S Verma, David P Lane, Wai Leong Tam, Ashok R Venkitaraman
Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities. Nature communications 14 (1) (2023)
Jieqiong Zhang, Zhenhua Hu, Hwa Hwa Chung, Yun Tian, Kah Weng Lau, Zheng Ser, Yan Ting Lim, Radoslaw Mikolaj Sobota, Hwei Fen Leong, Benjamin Jieming Chen, Clarisse Jingyi Yeo, Shawn Ying Xuan Tan, Jian Kang, Dennis Eng Kiat Tan, Ieng Fong Sou, Urszula Lucja McClurg, Manikandan Lakshmanan, Thamil Selvan Vaiyapuri, Anandhkumar Raju, Esther Sook Miin Wong, Vinay Tergaonkar, Ravisankar Rajarethinam, Elina Pathak, Wai Leong Tam, Ern Yu Tan, Wee-Wei Tee
Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis. Nature communications 14 (1) (2023)
Xiaosai Yao, Jing Han Hong, Amrita M Nargund, Michelle Shu Wen Ng, Hong Lee Heng, Zhimei Li, Peiyong Guan, Masahiro Sugiura, Pek Lim Chu, Loo Chien Wang, Xiaofen Ye, James Qu, Xiu Yi Kwek, Jeffrey Chun Tatt Lim, Wen Fong Ooi, Joanna Koh, Zhenxun Wang, You-Fu Pan, Yan Shan Ong, Kiat-Yi Tan, Jian Yuan Goh, Sheng Rong Ng, Luca Pignata, Dachuan Huang, Alexander Lezhava, Su Ting Tay, Minghui Lee, Xun Hui Yeo, Wai Leong Tam, Sun Young Rha, Shang Li, Ernesto Guccione, P Andrew Futreal, Jing Tan, Joe Poh Sheng Yeong, Wanjin Hong, Robert Yauch, Kenneth Tou-En Chang, Radoslaw Mikolaj Sobota, Patrick Boon-Ooi Tan, Bin Tean Teh
PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma. Nature cell biology (2023)
Xiaosai Yao, Jing Han Hong, Amrita M Nargund, Michelle Shu Wen Ng, Hong Lee Heng, Zhimei Li, Peiyong Guan, Masahiro Sugiura, Pek Lim Chu, Loo Chien Wang, Xiaofen Ye, James Qu, Xiu Yi Kwek, Jeffrey Chun Tatt Lim, Wen Fong Ooi, Joanna Koh, Zhenxun Wang, You-Fu Pan, Yan Shan Ong, Kiat-Yi Tan, Jian Yuan Goh, Sheng Rong Ng, Luca Pignata, Dachuan Huang, Alexander Lezhava, Su Ting Tay, Minghui Lee, Xun Hui Yeo, Wai Leong Tam, Sun Young Rha, Shang Li, Ernesto Guccione, P Andrew Futreal, Jing Tan, Joe Poh Sheng Yeong, Wanjin Hong, Robert Yauch, Kenneth Tou-En Chang, Radoslaw Mikolaj Sobota, Patrick Boon-Ooi Tan, Bin Tean Teh
PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma. Nature cell biology (2023)
Frances Karla Kusuma, Aishvaryaa Prabhu, Galen Tieo, Syed Moiz Ahmed, Pushkar Dakle, Wai Khang Yong, Elina Pathak, Vikas Madan, Yan Yi Jiang, Wai Leong Tam, Dennis Kappei, Peter Dröge, H Phillip Koeffler, Maya Jeitany
Signalling inhibition by ponatinib disrupts productive alternative lengthening of telomeres (ALT). Nature communications 14 (1) (2023)
Jieqiong Zhang, Zhenhua Hu, Hwa Hwa Chung, Yun Tian, Kah Weng Lau, Zheng Ser, Yan Ting Lim, Radoslaw Mikolaj Sobota, Hwei Fen Leong, Benjamin Jieming Chen, Clarisse Jingyi Yeo, Shawn Ying Xuan Tan, Jian Kang, Dennis Eng Kiat Tan, Ieng Fong Sou, Urszula Lucja McClurg, Manikandan Lakshmanan, Thamil Selvan Vaiyapuri, Anandhkumar Raju, Esther Sook Miin Wong, Vinay Tergaonkar, Ravisankar Rajarethinam, Elina Pathak, Wai Leong Tam, Ern Yu Tan, Wee-Wei Tee
Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis. Nature communications 14 (1) (2023)
Xun Hui Yeo, Vignesh Sundararajan, Zhengwei Wu, Zi Jin Cheryl Phua, Yin Ying Ho, Esther Kai Lay Peh, Yi-Chia Chiu, Tuan-Zea Tan, Dennis Kappei, Ying Swan Ho, David Shao Peng Tan, Wai Leong Tam, Ruby Yun-Ju Huang
Author Correction: The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer. Communications biology 6 (1) (2023)
Xiaosai Yao, Jing Han Hong, Amrita M Nargund, Michelle Shu Wen Ng, Hong Lee Heng, Zhimei Li, Peiyong Guan, Masahiro Sugiura, Pek Lim Chu, Loo Chien Wang, Xiaofen Ye, James Qu, Xiu Yi Kwek, Jeffrey Chun Tatt Lim, Wen Fong Ooi, Joanna Koh, Zhenxun Wang, You-Fu Pan, Yan Shan Ong, Kiat-Yi Tan, Jian Yuan Goh, Sheng Rong Ng, Luca Pignata, Dachuan Huang, Alexander Lezhava, Su Ting Tay, Minghui Lee, Xun Hui Yeo, Wai Leong Tam, Sun Young Rha, Shang Li, Ernesto Guccione, P Andrew Futreal, Jing Tan, Joe Poh Sheng Yeong, Wanjin Hong, Robert Yauch, Kenneth Tou-En Chang, Radoslaw Mikolaj Sobota, Patrick Boon-Ooi Tan, Bin Tean Teh
PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma. Nature cell biology 25 (5) (2023)
Xiaosai Yao, Jing Han Hong, Amrita M Nargund, Michelle Shu Wen Ng, Hong Lee Heng, Zhimei Li, Peiyong Guan, Masahiro Sugiura, Pek Lim Chu, Loo Chien Wang, Xiaofen Ye, James Qu, Xiu Yi Kwek, Jeffrey Chun Tatt Lim, Wen Fong Ooi, Joanna Koh, Zhenxun Wang, You-Fu Pan, Yan Shan Ong, Kiat-Yi Tan, Jian Yuan Goh, Sheng Rong Ng, Luca Pignata, Dachuan Huang, Alexander Lezhava, Su Ting Tay, Minghui Lee, Xun Hui Yeo, Wai Leong Tam, Sun Young Rha, Shang Li, Ernesto Guccione, P Andrew Futreal, Jing Tan, Joe Poh Sheng Yeong, Wanjin Hong, Robert Yauch, Kenneth Tou-En Chang, Radoslaw Mikolaj Sobota, Patrick Boon-Ooi Tan, Bin Tean Teh
PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma. Nature cell biology 25 (5) (2023)
Teresa Lai Fong Ho, May Yin Lee, Hui Chin Goh, Germaine Yi Ning Ng, Jane Jia Hui Lee, Srinivasaraghavan Kannan, Yan Ting Lim, Tianyun Zhao, Edwin Kok Hao Lim, Cheryl Zi Jin Phua, Yi Fei Lee, Rebecca Yi Xuan Lim, Perry Jun Hao Ng, Ju Yuan, Dedrick Kok Hong Chan, Bettina Lieske, Choon Seng Chong, Kuok Chung Lee, Jeffrey Hy Lum, Wai Kit Cheong, Khay-Guan Yeoh, Ker Kan Tan, Radoslaw Mikolaj Sobota, Chandra S Verma, David P Lane, Wai Leong Tam, Ashok R Venkitaraman
Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities. Nature communications 14 (1) (2023)
Jieqiong Zhang, Zhenhua Hu, Hwa Hwa Chung, Yun Tian, Kah Weng Lau, Zheng Ser, Yan Ting Lim, Radoslaw Mikolaj Sobota, Hwei Fen Leong, Benjamin Jieming Chen, Clarisse Jingyi Yeo, Shawn Ying Xuan Tan, Jian Kang, Dennis Eng Kiat Tan, Ieng Fong Sou, Urszula Lucja McClurg, Manikandan Lakshmanan, Thamil Selvan Vaiyapuri, Anandhkumar Raju, Esther Sook Miin Wong, Vinay Tergaonkar, Ravisankar Rajarethinam, Elina Pathak, Wai Leong Tam, Ern Yu Tan, Wee-Wei Tee
Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis. Nature communications 14 (1) (2023)
Teresa Lai Fong Ho, May Yin Lee, Hui Chin Goh, Germaine Yi Ning Ng, Jane Jia Hui Lee, Srinivasaraghavan Kannan, Yan Ting Lim, Tianyun Zhao, Edwin Kok Hao Lim, Cheryl Zi Jin Phua, Yi Fei Lee, Rebecca Yi Xuan Lim, Perry Jun Hao Ng, Ju Yuan, Dedrick Kok Hong Chan, Bettina Lieske, Choon Seng Chong, Kuok Chung Lee, Jeffrey Hy Lum, Wai Kit Cheong, Khay-Guan Yeoh, Ker Kan Tan, Radoslaw Mikolaj Sobota, Chandra S Verma, David P Lane, Wai Leong Tam, Ashok R Venkitaraman
Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities. Nature communications 14 (1) (2023)
Viktoriia Iakovleva, Anna Wuestefeld, Agnes Bee Leng Ong, Rong Gao, Neslihan Arife Kaya, May Yin Lee, Weiwei Zhai, Wai Leong Tam, Yock Young Dan, Torsten Wuestefeld
Mfap4: a promising target for enhanced liver regeneration and chronic liver disease treatment. NPJ Regenerative medicine 8 (1) (2023)
Jieqiong Zhang, Zhenhua Hu, Hwa Hwa Chung, Yun Tian, Kah Weng Lau, Zheng Ser, Yan Ting Lim, Radoslaw Mikolaj Sobota, Hwei Fen Leong, Benjamin Jieming Chen, Clarisse Jingyi Yeo, Shawn Ying Xuan Tan, Jian Kang, Dennis Eng Kiat Tan, Ieng Fong Sou, Urszula Lucja McClurg, Manikandan Lakshmanan, Thamil Selvan Vaiyapuri, Anandhkumar Raju, Esther Sook Miin Wong, Vinay Tergaonkar, Ravisankar Rajarethinam, Elina Pathak, Wai Leong Tam, Ern Yu Tan, Wee-Wei Tee
Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis. Nature communications 14 (1) (2023)
Upadhyayula S Srinivas, Norbert S C Tay, Patrick Jaynes, Akshaya Anbuselvan, Gokula K Ramachandran, Joanna D Wardyn, Michal Marek Hoppe, Phuong Mai Hoang, Yanfen Peng, Sherlly Lim, May Yin Lee, Praveen C Peethala, Omer An, Akshay Shendre, Bryce W Q Tan, Sherlyn Jemimah, Manikandan Lakshmanan, Longyu Hu, Rekha Jakhar, Karishma Sachaphibulkij, Lina H K Lim, Shazib Pervaiz, Karen Crasta, Henry Yang, Patrick Tan, Chao Liang, Lena Ho, Vartika Khanchandani, Dennis Kappei, Wei Peng Yong, David S P Tan, Matteo Bordi, Silvia Campello, Wai Leong Tam, Christian Frezza, Anand D Jeyasekharan
PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production. Oncogene 41 (13) (2022)
Yu-Hsiu Wang, Teresa L F Ho, Anushya Hariharan, Hui Chin Goh, Yao Liang Wong, Nicole S Verkaik, May Yin Lee, Wai Leong Tam, Dik C van Gent, Ashok R Venkitaraman, Michael P Sheetz, David P Lane
Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity. Proceedings of the National Academy of Sciences of the United States of America 119 (10) (2022)
Phuong Hoang Diem Nguyen, Martin Wasser, Chong Teik Tan, Chun Jye Lim, Hannah L H Lai, Justine Jia Wen Seow, Ramanuj DasGupta, Cheryl Z J Phua, Siming Ma, Jicheng Yang, Sheena D/O Suthen, Wai Leong Tam, Tony K H Lim, Joe Yeong, Wei Qiang Leow, Yin Huei Pang, Gwyneth Soon, Tracy Jiezhen Loh, Wei Keat Wan, Chung Yip Chan, Peng Chung Cheow, Han Chong Toh, Alfred Kow, Yock Young Dan, Juinn Huar Kam, Shridhar Ganpathi Iyer, Krishnakumar Madhavan, Alexander Chung, Glenn K Bonney, Brian K P Goh, Nai Yang Fu, Victor C Yu, Weiwei Zhai, Salvatore Albani, Pierce Kah-Hoe Chow, Valerie Chew
Trajectory of immune evasion and cancer progression in hepatocellular carcinoma. Nature communications 13 (1) (2022)
Nirmala Arul Rayan, Vibhor Kumar, Jonathan Aow, Naghmeh Rastegar, Michelle Gek Liang Lim, Nicholas O'Toole, Edita Aliwarga, Danusa Mar Arcego, Hui Ting Grace Yeo, Jen Yi Wong, May Yin Lee, Florian Schmidt, Hajira Shreen Haja, Wai Leong Tam, Tie-Yuan Zhang, Josie Diorio, Christoph Anacker, Rene Hen, Carine Parent, Michael J Meaney, Shyam Prabhakar
Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling. Molecular psychiatry (2022)
Phuong H D Nguyen, Siming Ma, Cheryl Z J Phua, Neslihan Arife Kaya, Hannah L H Lai, Chun Jye Lim, Jia Qi Lim, Martin Wasser, Liyun Lai, Wai Leong Tam, Tony K H Lim, Wei Keat Wan, Tracy Loh, Wei Qiang Leow, Yin Huei Pang, Chung Yip Chan, Ser Yee Lee, Peng Chung Cheow, Han Chong Toh, Florent Ginhoux, Shridhar Iyer, Alfred W C Kow, Yock Young Dan, Alexander Chung, Glen K Bonney, Brian K P Goh, Salvatore Albani, Pierce Kah-Hoe Chow, Weiwei Zhai, Valerie Chew
Author Correction: Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma. Nature communications 12 (1) (2021)
Phuong H D Nguyen, Siming Ma, Cheryl Z J Phua, Neslihan Arife Kaya, Hannah L H Lai, Chun Jye Lim, Jia Qi Lim, Martin Wasser, Liyun Lai, Wai Leong Tam, Tony K H Lim, Wei Keat Wan, Tracy Loh, Wei Qiang Leow, Yin Huei Pang, Chung Yip Chan, Ser Yee Lee, Peng Chung Cheow, Han Chong Toh, Florent Ginhoux, Shridhar Iyer, Alfred W C Kow, Yock Young Dan, Alexander Chung, Glen K Bonney, Brian K P Goh, Salvatore Albani, Pierce Kah-Hoe Chow, Weiwei Zhai, Valerie Chew
Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma. Nature communications 12 (1) (2021)
Ser Yue Loo, Li Ping Toh, William Haowei Xie, Elina Pathak, Wilson Tan, Siming Ma, May Yin Lee, S Shatishwaran, Joanna Zhen Zhen Yeo, Ju Yuan, Yin Ying Ho, Esther Kai Lay Peh, Magendran Muniandy, Federico Torta, Jack Junjie Chan, Tira Jing Ying Tan, Yirong R Sim, Veronique Kiak Mien Tan, Kiat Tee Benita Tan, Preetha Madhukumar, Wei Sean Yong, Kong Wee Ong, Chow Yin Wong, Puay Hoon Tan, Yoon Sim Yap, Lih-Wen Deng, Rebecca A Dent, Roger Sik Yin Foo, Markus R Wenk, Soo-Chin Lee, Ying Swan Ho, Elaine Hsuen Lim, Wai Leong Tam
Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer. Science advances 7 (41) (2021)
Khi Pin Chua, Yvonne H F Teng, Aaron C Tan, Angela M Takano, Jacob J S Alvarez, Rahul Nahar, Neha Rohatgi, Gillianne G Y Lai, Zaw Win Aung, Joe P S Yeong, Kiat Hon Lim, Marjan Mojtabavi Naeini, Irfahan Kassam, Amit Jain, Wan Ling Tan, Apoorva Gogna, Chow Wei Too, Ravindran Kanesvaran, Quan Sing Ng, Mei Kim Ang, Tanujaa Rajasekaran, Devanand Anantham, Ghee Chee Phua, Bien Soo Tan, Yin Yeng Lee, Lanying Wang, Audrey S M Teo, Alexis Jiaying Khng, Ming Jie Lim, Lisda Suteja, Chee Keong Toh, Darren Wan-Teck Lim, N Gopalakrishna Iyer, Wai Leong Tam, Eng-Huat Tan, Weiwei Zhai, Axel Maximilian Hillmer, Anders J Skanderup, Daniel S W Tan
Integrative Profiling of T790M-Negative EGFR-Mutated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (21) (2021)
Zhengwei Wu, Yi Fei Lee, Xun Hui Yeo, Ser Yue Loo, Wai Leong Tam
Shifting the Gears of Metabolic Plasticity to Drive Cell State Transitions in Cancer. Cancers 13 (6) (2021)
Jianbin Chen, Hechuan Yang, Audrey Su Min Teo, Lidyana Bte Amer, Faranak Ghazi Sherbaf, Chu Quan Tan, Jacob Josiah Santiago Alvarez, Bingxin Lu, Jia Qi Lim, Angela Takano, Rahul Nahar, Yin Yeng Lee, Cheryl Zi Jin Phua, Khi Pin Chua, Lisda Suteja, Pauline Jieqi Chen, Mei Mei Chang, Tina Puay Theng Koh, Boon-Hean Ong, Devanand Anantham, Anne Ann Ling Hsu, Apoorva Gogna, Chow Wei Too, Zaw Win Aung, Yi Fei Lee, Lanying Wang, Tony Kiat Hon Lim, Andreas Wilm, Poh Sum Choi, Poh Yong Ng, Chee Keong Toh, Wan-Teck Lim, Siming Ma, Bing Lim, Jin Liu, Wai Leong Tam, Anders Jacobsen Skanderup, Joe Poh Sheng Yeong, Eng-Huat Tan, Caretha L Creasy, Daniel Shao-Weng Tan, Axel Maximilian Hillmer, Weiwei Zhai
Genomic landscape of lung adenocarcinoma in East Asians. Nature genetics 52 (2) (2020)
Zhenxun Wang, Lian Yee Yip, Jia Hui Jane Lee, Zhengwei Wu, Hui Yi Chew, Pooi Kiat William Chong, Chin Chye Teo, Heather Yin-Kuan Ang, Kai Lay Esther Peh, Ju Yuan, Siming Ma, Li Shi Kimberly Choo, Nurhidayah Basri, Xia Jiang, Qiang Yu, Axel Maximilian Hillmer, Wan Teck Lim, Tony Kiat Hon Lim, Angela Takano, Eng Huat Tan, Daniel Shao Weng Tan, Ying Swan Ho, Bing Lim, Wai Leong Tam
Methionine is a metabolic dependency of tumor-initiating cells. Nature medicine 25 (5) (2019)
Rahul Nahar, Weiwei Zhai, Tong Zhang, Angela Takano, Alexis J Khng, Yin Yeng Lee, Xingliang Liu, Chong Hee Lim, Tina P T Koh, Zaw Win Aung, Tony Kiat Hon Lim, Lavanya Veeravalli, Ju Yuan, Audrey S M Teo, Cheryl X Chan, Huay Mei Poh, Ivan M L Chua, Audrey Ann Liew, Dawn Ping Xi Lau, Xue Lin Kwang, Chee Keong Toh, Wan-Teck Lim, Bing Lim, Wai Leong Tam, Eng-Huat Tan, Axel Maximilian Hillmer, Daniel S W Tan
Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing. Nature communications 9 (1) (2018)
Jian Yuan Goh, Min Feng, Wenyu Wang, Gokce Oguz, Siti Maryam J M Yatim, Puay Leng Lee, Yi Bao, Tse Hui Lim, Panpan Wang, Wai Leong Tam, Annette R Kodahl, Maria B Lyng, Suman Sarma, Selena Y Lin, Alexander Lezhava, Yoon Sim Yap, Alvin S T Lim, Dave S B Hoon, Henrik Jørn Ditzel, Soo Chin Lee, Ern Yu Tan, Qiang Yu
Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence. Nature medicine 23 (11) (2017)

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Publication Activity (10 Years)

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Wai Leong Tam