Early-phase prothrombin time-international normalized ratio in acute liver injury indicates the timing of therapeutic intervention and predicts prognostic improvement.

Kotaro Kumagai Seiichi MawatariAkihiro MoriuchiKohei OdaYasuhiro TakikawaNaoya KatoShigeto OdaKazuaki InoueShuji TeraiTakuya GendaMasahito ShimizuIsao SakaidaSatoshi MochidaAkio Ido

Published in: Hepatology research : the official journal of the Japan Society of Hepatology (2022)

Early-phase changes in the PT-INR can predict the prognosis of patients with acute liver injury and acute liver failure. Furthermore, PT-INR ≥1.3 could be an interventional marker, whereas PT-INR <1.3 after 1 week could reflect prognostic improvement.

Keyphrases

liver injury
liver failure
drug induced
hepatitis b virus
randomized controlled trial
clinical trial
intensive care unit
respiratory failure
aortic dissection
mechanical ventilation