Effectiveness and Cost-Effectiveness of Prophylactic Voriconazole and Fluconazole Regarding Prevention of Post-hematopoietic Stem Cell Transplantation Invasive Fungal Infection and Its Related Death: A Single Center Experience.

Amro Mohamed Sedky El-Ghammaz Maha El-ZimaityAmal Mostafa ElafifiEssam AbdelwahedMohamed Mahmoud MoussaYasmin Ahmed AboelmagdMohamed Gamal KotobHebatullah Magdy Fares

Published in: Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion (2020)

Voriconazole does not differ from fluconazole regarding its efficacy in prevention of IFI and IRD and does not improve OS and FFS in both allogeneic HSCT and ASCT settings. Voriconazole is cost-effective regarding protection from IFI and IRD in allogeneic HSCT but not cost-effective in ASCT.

Keyphrases

hematopoietic stem cell
stem cell transplantation
candida albicans
bone marrow
randomized controlled trial
systematic review
high dose
acute myeloid leukemia
low dose