Chimeric mice with humanized liver as a model for testing organophosphate and carbamate pesticide exposure.

Hiroshi SuemizuKenji KawaiNorie MurayamaMasato NakamuraHiroshi Yamazaki

Published in: Pest management science (2018)

Changes in plasma BuChE activity in chimeric mice with humanized liver clearly reflected the exposure levels of OP and CM pesticides. These results suggest that the humanized-liver mouse model may be suitable for estimating levels of exposure to these pesticides in humans. © 2017 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Keyphrases

risk assessment
mouse model
monoclonal antibody
cell therapy
high fat diet induced
public health
stem cells
gas chromatography
randomized controlled trial
mesenchymal stem cells
metabolic syndrome
skeletal muscle
adipose tissue
bone marrow
tandem mass spectrometry