Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma.
Nazanin Zounemat KermaniWoo-Jung SongYusef BadiAli VersiYike GuoKai SunPank BhavsarPeter HowarthSven-Erik DahlenPeter J SterkRatko DjukanovicIan M AdcockKian Fan Chungnull nullPublished in: Respiratory research (2021)
Levels of ACE2 and FURIN may differ by clinical or molecular phenotypes of asthma. Sputum FURIN expression levels were strongly associated with neutrophilic inflammation and with inflammasome activation. This might indicate the potential for a greater morbidity and mortality outcome from SARS-CoV-2 infection in neutrophilic severe asthma.
Keyphrases
- gene expression
- cystic fibrosis
- lung function
- chronic obstructive pulmonary disease
- mycobacterium tuberculosis
- pulmonary tuberculosis
- angiotensin converting enzyme
- angiotensin ii
- poor prognosis
- allergic rhinitis
- oxidative stress
- dna methylation
- binding protein
- respiratory syndrome coronavirus
- air pollution
- sars cov