Global DNA Methylation Analysis of Cancer-Associated Fibroblasts Reveals Extensive Epigenetic Rewiring Linked with RUNX1 Upregulation in Breast Cancer Stroma.

Coral Halperin Joschka Hey Dieter Weichenhan Yaniv Stein Shimrit Mayer Pavlo Lutsik Christoph Plass Ruth Scherz-Shouval

Published in: Cancer research (2022)

The first genome-wide map of DNA methylation in breast cancer-associated fibroblasts unravels a previously unknown facet of the dynamic plasticity of the stroma, with far-reaching therapeutic implications.

Keyphrases

dna methylation
genome wide
gene expression
extracellular matrix
copy number
transcription factor
poor prognosis
cell proliferation
signaling pathway
high density