Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health.
François BrialJulien ChillouxTrine NielsenSara Vieira-SilvaGwen FalonyPetros AndrikopoulosMichael OlanipekunLesley HoylesFatima DjouadiAna L NevesAndrea Rodriguez-MartinezGhiwa Ishac MouawadNicolas PonsSofia ForslundEmmanuelle Le-ChatelierAurélie Le LayJeremy NicholsonTorben HansenTuulia HyötyläinenKarine ClémentMatej OresicPeer BorkStanislav Dusko EhrlichJeroen RaesOluf Borbye PedersenDominique GauguierMarc Emmanuel DumasPublished in: Gut (2021)
Our human and experimental studies show that a high urine hippurate concentration is a general marker of metabolic health, and in the context of obesity induced by high-fat diets, hippurate contributes to metabolic improvements, highlighting its potential as a mediator of metabolic health.