Plasma Proteomics Identifies B2M as a Regulator of Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction.
Jia-Rong JhengJacqueline T DesJardinYi-Yun ChenJoshua R HuotYang BaiTodd CookLainey M HibbardJennifer M RuppAmanda FisherYingze ZhangJulio D DuarteAnkit A DesaiRoberto F MachadoMarc A SimonYen-Chun LaiPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Patients with PH-HFpEF display higher circulating and skeletal muscle expression levels of B2M, the magnitude of which correlates with disease severity. Our findings also reveal a previously unknown pathogenic role of B2M in the regulation of pulmonary vascular proliferative remodeling and PH-HFpEF. These data suggest that circulating and skeletal muscle B2M can be promising targets for the management of PH-HFpEF.