Investigation of epigenetic regulatory networks associated with autism spectrum disorder (ASD) by integrated global LINE-1 methylation and gene expression profiling analyses.

Chayanin TangsuwansriThanit SaeliwSurangrat ThongkornWeerasak ChonchaiyaKanya SuphapeetipornApiwat MutiranguraTewin TencomnaoValerie Wailin HuTewarit Sarachana

Published in: PloS one (2018)

In ASD individuals with severe language impairment, LINE-1 methylation was reduced and correlated with the expression levels of LINE-1 and the LINE-1-inserted DEG C1orf27. Our findings highlight the association of LINE-1 with DEGs in ASD blood samples and warrant further investigation. The molecular mechanisms of LINE-1 and the effects of its methylation in ASD pathobiology deserve further study.

Keyphrases

autism spectrum disorder
gene expression
dna methylation
attention deficit hyperactivity disorder
intellectual disability
genome wide
poor prognosis
early onset
transcription factor
single cell