Risk factors affecting COVID-19 vaccine effectiveness identified from 290 cross-country observational studies until February 2022: a meta-analysis and meta-regression.

Marek PetrasRoman MáčalíkDaniela JanovskáAlexander M ČelkoJana DáňováEliška SelingerJonáš DolečekSylva NeradováMartina FranklováPavel DlouhýJozef RosinaIvana Králová Lesná

Published in: BMC medicine (2022)

Full vaccination provided an early high, yet waning level of protection against COVID-19 of any severity with a strong impact on the high-risk population. Moreover, the potential risk of new antigenically distinct variants should not be underestimated, and any future immunization strategy should include variant-updated vaccines.

Keyphrases

coronavirus disease
sars cov
randomized controlled trial
systematic review
respiratory syndrome coronavirus
current status
copy number
risk assessment
climate change