Downregulation of Calreticulin and Annexin A2 Expression in Acquired Middle Ear Cholesteatoma by 2-DE Analysis.

Ning-Chia ChangYu-Jen WuLing-Feng WangLeong-Perng ChanChee-Yin ChaiWan-Tzu Chen MsShih-Meng TsaiChen-Yu ChienKuen-Yao Ho

Published in: The Annals of otology, rhinology, and laryngology (2022)

Our data suggests that CRT and AnxA2 downregulation are seen in cholesteatoma compared to retroauricular skin. We speculate that the reduced expression of CRT and the persistent inflammatory response play important roles in the epithelial proliferation of cholesteatoma.

Keyphrases

poor prognosis
inflammatory response
signaling pathway
cell proliferation
cardiac resynchronization therapy
binding protein
long non coding rna
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immune response
soft tissue
atrial fibrillation
artificial intelligence