In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression.
Hélène Le RibeuzAudrey CourboulinMaria-Rosa GhignaMélanie LambertAurélie HautefortMarc HumbertDavid MontaniSylvia Cohen-KaminskyFrédéric PerrosFabrice AntignyPublished in: Respiratory research (2020)
We confirmed that in vivo inhibition of miR-138-5p reduces the development of PH in experimental MCT-PH. The possible curative mechanisms involve at least the normalization of lung KCNK3 as well as SLC45A3 expression.