In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression.

Hélène Le RibeuzAudrey CourboulinMaria-Rosa GhignaMélanie LambertAurélie HautefortMarc HumbertDavid MontaniSylvia Cohen-KaminskyFrédéric PerrosFabrice Antigny

Published in: Respiratory research (2020)

We confirmed that in vivo inhibition of miR-138-5p reduces the development of PH in experimental MCT-PH. The possible curative mechanisms involve at least the normalization of lung KCNK3 as well as SLC45A3 expression.

Keyphrases

pulmonary hypertension
poor prognosis
pulmonary arterial hypertension
pulmonary artery
binding protein
high glucose
long non coding rna
rectal cancer
oxidative stress
endothelial cells
prognostic factors