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In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression.

Hélène Le RibeuzAudrey CourboulinMaria-Rosa GhignaMélanie LambertAurélie HautefortMarc HumbertDavid MontaniSylvia Cohen-KaminskyFrédéric PerrosFabrice Antigny
Published in: Respiratory research (2020)
We confirmed that in vivo inhibition of miR-138-5p reduces the development of PH in experimental MCT-PH. The possible curative mechanisms involve at least the normalization of lung KCNK3 as well as SLC45A3 expression.
Keyphrases
  • pulmonary hypertension
  • poor prognosis
  • pulmonary arterial hypertension
  • pulmonary artery
  • binding protein
  • high glucose
  • long non coding rna
  • rectal cancer
  • oxidative stress
  • endothelial cells
  • prognostic factors