Anti-Proliferative and Anti-Inflammatory Lanostane Triterpenoids from the Polish Edible Mushroom Macrolepiota procera.
He-Ping ChenZhen-Zhu ZhaoZheng-Hui LiYing HuangShuai-Bing ZhangYang TangJian-Neng YaoLin ChenMasahiko IsakaTao FengJi-Kai LiuPublished in: Journal of agricultural and food chemistry (2018)
This study features the isolation and identification of 12 lanostane-type triterpenoids, namely lepiotaprocerins A-L, 1-12, from the fruiting bodies of the Poland-collected edible mushroom Macrolepiota procera. The structures and the absolute configurations of the new compounds were ambiguously established by extensive spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction analyses. Structurally, lepiotaprocerins A-F, 1-6, are distinguished by the presence of a rare "1-en-1,11-epoxy" moiety which has not been previously described in the lanostane class. Biologically, lepiotaprocerins A-F, 1-6, displayed more significant inhibitions of nitric oxide (NO) production than the positive control L- NG-monomethyl arginine (L-NMMA) (IC50 47.1 μM), and lepiotaprocerins G-L, 7-12, showed various cytotoxicity potencies against a panel of human cancer cell lines. Compound 9 also displayed antitubercular activity against Mycobacterium tuberculosis H37Ra with a minimal inhibitory concentration (MIC) 50 μg/mL.
Keyphrases
- nitric oxide
- mycobacterium tuberculosis
- anti inflammatory
- endothelial cells
- high resolution
- papillary thyroid
- rheumatoid arthritis
- nitric oxide synthase
- hydrogen peroxide
- electron microscopy
- squamous cell carcinoma
- induced pluripotent stem cells
- pulmonary tuberculosis
- disease activity
- mass spectrometry
- pluripotent stem cells
- young adults
- lymph node metastasis
- monte carlo
- bioinformatics analysis