SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
Waradon SungnakNi HuangChristophe BécavinMarijn BergRachel QueenMonika LitvinukovaCarlos Talavera-LópezHenrike MaatzDaniel ReichartFotios SampaziotisKaylee B WorlockMasahiro YoshidaJosephine L Barnesnull nullPublished in: Nature medicine (2020)
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
Keyphrases
- sars cov
- single cell
- high efficiency
- respiratory syndrome coronavirus
- genome wide
- innate immune
- bioinformatics analysis
- induced apoptosis
- genome wide identification
- endothelial cells
- electronic health record
- rna seq
- poor prognosis
- big data
- minimally invasive
- dna methylation
- cell cycle arrest
- genome wide analysis
- optical coherence tomography
- mass spectrometry
- chronic rhinosinusitis
- signaling pathway
- risk assessment
- cell proliferation
- data analysis
- climate change
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- single molecule