Potential therapeutic effects of cyanidin-3-O-glucoside on rheumatoid arthritis by relieving inhibition of CD38+ NK cells on Treg cell differentiation.
Hongxing WangShutong LiGuoqing ZhangHui WuXiaotian ChangPublished in: Arthritis research & therapy (2019)
C3G has therapeutic effects on CIA and RA. C3G decreased the proportion of CD38+ cells, RASF proliferation, and proinflammatory cytokine secretion, and it increased the Treg cell proportion. C3G also elevated Sirt6 expression to suppress NKG2D expression, increase TNF-α secretion, and decrease IFN-γ secretion in CD38+ NK cells, which stimulates MNCs to differentiate into Treg cells. This study also demonstrates that the inhibition of Treg cell differentiation in MNCs by CD38+ NK cells is a potential cause of the immune imbalance in RA and CIA.
Keyphrases
- nk cells
- rheumatoid arthritis
- induced apoptosis
- poor prognosis
- cell cycle arrest
- disease activity
- oxidative stress
- signaling pathway
- ankylosing spondylitis
- immune response
- binding protein
- single cell
- interstitial lung disease
- stem cells
- long non coding rna
- systemic lupus erythematosus
- endoplasmic reticulum stress
- systemic sclerosis
- cell therapy
- ischemia reperfusion injury
- human health
- idiopathic pulmonary fibrosis