Ni-Catalyzed Carboxylation of Aziridines en Route to β-Amino Acids.
Jacob DaviesDaniel Janssen-MüllerDmitry P ZiminCraig S DayTomoyuki YanagiJonas ElfertRúben MartínPublished in: Journal of the American Chemical Society (2021)
A Ni-catalyzed reductive carboxylation of N-substituted aziridines with CO2 at atmospheric pressure is disclosed. The protocol is characterized by its mild conditions, experimental ease, and exquisite chemo- and regioselectivity pattern, thus unlocking a new catalytic blueprint to access β-amino acids, important building blocks with considerable potential as peptidomimetics.