Exposure to Progestin 17-OHPC Induces Gastrointestinal Dysfunction through Claudin-1 Suppression in Female Mice with Increased Anxiety-Like Behaviors.

Liqin ZengXiaozhuang ZhangQingjun ShenLi HeXiaohan LiuXiangyue ZengQiaozhu WuIrene MaShuangyun ZhengLiqin ChengLing LiPaul Yao

Published in: Neuroendocrinology (2024)

17-OHPC suppresses CLDN1 expression through VDR, contributing to GI dysfunction in female mice, distinct from 17-OHPC-induced anxiety-like behaviors. This study reveals a new mechanism and potential negative impact of progestin exposure on the GI tract, alongside inducing anxiety-like behaviors in female mice.

Keyphrases

high fat diet induced
sleep quality
oxidative stress
poor prognosis
wild type
type diabetes
high glucose
depressive symptoms
metabolic syndrome
binding protein
endothelial cells