Extended Versus Standard Antibiotic Course Duration in Children <5 Years of Age Hospitalized With Community-acquired Pneumonia in High-risk Settings: Four-week Outcomes of a Multicenter, Double-blind, Parallel, Superiority Randomized Controlled Trial.
Gabrielle Britt McCallumSiew M FongKeith GrimwoodAnna Marie NathanCatherine Ann ByrnesMong H OoiNachal NachiappanNoorazlina SaariPeter S MorrisTsin Wen YeoRobert S WareBlueren W ElogiusVictor Maduabuchi OguomaStephanie T YerkovichJessie A de BruyneKatrina A LawrenceBilawara LeeJohn W UphamPaul J TorzilloAnne Bernadette ChangPublished in: The Pediatric infectious disease journal (2022)
Among children hospitalized with pneumonia and at-risk of chronic respiratory illnesses, an extended antibiotic course was not superior to a standard course at achieving clinical cure at 4 weeks. Additional research will identify if an extended course provides longer-term benefits.