Long Non-Coding RNAs in Hepatitis B Virus-Related Hepatocellular Carcinoma: Regulation, Functions, and Underlying Mechanisms.
Lipeng QiuTao WangXiuquan XuYihang WuQi TangKeping ChenPublished in: International journal of molecular sciences (2017)
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer death in the world. Hepatitis B virus (HBV) and its X gene-encoded protein (HBx) play important roles in the progression of HCC. Although long non-coding RNAs (lncRNAs) cannot encode proteins, growing evidence indicates that they play essential roles in HCC progression, and contribute to cell proliferation, invasion and metastasis, autophagy, and apoptosis by targeting a large number of pivotal protein-coding genes, miRNAs, and signaling pathways. In this review, we briefly outline recent findings of differentially expressed lncRNAs in HBV-related HCC, with particular focus on several key lncRNAs, and discuss their regulation by HBV/HBx, their functions, and their underlying molecular mechanisms in the progression of HCC.
Keyphrases
- hepatitis b virus
- long non coding rna
- genome wide identification
- poor prognosis
- liver failure
- papillary thyroid
- cell proliferation
- genome wide analysis
- signaling pathway
- endoplasmic reticulum stress
- oxidative stress
- cell death
- genome wide
- network analysis
- pi k akt
- protein protein
- cell cycle arrest
- cell cycle
- dna methylation
- young adults
- childhood cancer
- amino acid
- induced apoptosis
- small molecule