The clinical implications and molecular features of intrahepatic cholangiocarcinoma with perineural invasion.

Xian-Long MengJia-Cheng LuHai-Ying ZengZhen ChenXiao-Jun GuoChao GaoYan-Zi PeiShu-Yang HuMu YeQi-Man SunGuo-Huang YangJia-Bin CaiPei-Xin HuangLei YvLv ZhangYing-Hong ShiAi-Wu KeJian ZhouJia FanYi ChenXiao-Yong HuangGuo-Ming Shi

Published in: Hepatology international (2022)

Our study deciphered the genomic features and the immune suppressive metastasis-prone niche in ICC with PNI. Patients with PNI showed a poor prognosis after surgery but a good response to adjuvant chemotherapy.

Keyphrases

poor prognosis
long non coding rna
copy number
cell migration
single molecule
dna methylation