ENO1 expression and Erk phosphorylation in PDAC and their effects on tumor cell apoptosis in a hypoxic microenvironment.
Huizhi SunJing MoRunfen ChengFan LiYue LiYuhong GuoYanlei LiYanhui ZhangXiaoyu BaiYalei WangXueyi DongDanfang ZhangBaocun SunPublished in: Cancer biology & medicine (2022)
Hypoxia-induced ENO1 expression promotes ERK phosphorylation and inhibits apoptosis, thus leading to PDAC survival and invasion. These results suggest that ENO1 is a potential therapeutic target for PDAC.