Low agreement between various eGFR formulae in pediatric and young adult ADPKD patients.
Pieter SchellekensMarcelien VerjansPeter JanssensAngélique DachyStéphanie De RechterLuc BreysemKarel AllegaertBert BammensRudi VennekensPieter VermeerschHans PottelDjalila MekahliPublished in: Pediatric nephrology (Berlin, Germany) (2023)
The most widely used methods to calculate eGFR in ADPKD children (CKiD and CKiDU25 equations) were associated with unexpected age or sex differences. The FAS equations were age- and sex-independent in our cohort. Hence, the switch from the CKiD to CKD-EPI equation at the transition from pediatric to adult care causes implausible jumps in eGFR, which could be misinterpreted. Having reliable methods to calculate eGFR is indispensable for clinical follow-up and clinical trials. A higher resolution version of the Graphical abstract is available as Supplementary information.
Keyphrases
- small cell lung cancer
- epidermal growth factor receptor
- tyrosine kinase
- young adults
- end stage renal disease
- clinical trial
- chronic kidney disease
- childhood cancer
- newly diagnosed
- ejection fraction
- palliative care
- prognostic factors
- randomized controlled trial
- polycystic kidney disease
- quality improvement
- pain management
- open label
- phase ii