ICAM-1 on the luminal surface of endothelial cells is induced to a greater extent in mouse retina than in other tissues in diabetes.
Emma M LessieurHaitao LiuAicha SaadaneYunpeng DuJianying KiserTimothy S KernPublished in: Diabetologia (2022)
The diabetes-induced upregulation of ICAM-1 on the luminal surface of the vascular endothelium varies considerably among tissues and is highest in the retina. Induction of ICAM-1 on retinal vascular endothelial cells in diabetes is influenced by vision-related processes in photoreceptor cells. The unique presence of photoreceptors in the retina might contribute to the greater susceptibility of this tissue to vascular disease in diabetes.
Keyphrases
- endothelial cells
- high glucose
- type diabetes
- cardiovascular disease
- glycemic control
- diabetic retinopathy
- optic nerve
- gene expression
- diabetic rats
- induced apoptosis
- optical coherence tomography
- drug induced
- oxidative stress
- signaling pathway
- cell proliferation
- poor prognosis
- endoplasmic reticulum stress
- cell cycle arrest