PU.1 regulates Alzheimer's disease-associated genes in primary human microglia.

Justin RustenhovenAmy M SmithLeon C SmythDeidre JanssonEmma L ScotterMolly E V SwansonMiranda AalderinkNatacha CoppietersPritika NarayanRenee HandleyChris OverallThomas I H ParkPatrick SchwederPeter HeppnerMaurice A CurtisRichard L M FaullMichael Dragunow

Published in: Molecular neurodegeneration (2018)

Collectively, these results suggest that attenuating PU.1 may be a valid therapeutic approach to limit microglial-mediated inflammatory responses in AD and demonstrate utility of vorinostat for this purpose.

Keyphrases

inflammatory response
endothelial cells
neuropathic pain
genome wide
induced pluripotent stem cells
lipopolysaccharide induced
cognitive decline
lps induced
pluripotent stem cells
dna methylation
bioinformatics analysis
genome wide identification
mild cognitive impairment