Expression of PD-1 and Tim-3 markers of T-cell exhaustion is associated with CD4 dynamics during the course of untreated and treated HIV infection.
Norma RallónMarcial GarcíaJavier García-SamaniegoAlfonso CabelloBeatriz ÁlvarezClara RestrepoSara NistalMiguel GórgolasJosé M BenitoPublished in: PloS one (2018)
Our results suggest that PD1 and Tim3 markers of exhaustion have a pivotal role in CD4 dynamics in HIV patients and its down-regulation would be a desirable effect of immunotherapies aimed to restore CD4 T-cell pool during progression of HIV infection.
Keyphrases
- antiretroviral therapy
- end stage renal disease
- newly diagnosed
- hiv infected
- human immunodeficiency virus
- hiv positive
- ejection fraction
- poor prognosis
- chronic kidney disease
- prognostic factors
- hepatitis c virus
- hiv aids
- peritoneal dialysis
- hiv testing
- nk cells
- binding protein
- men who have sex with men
- patient reported